Nurse Practitioner Salary in South Carolina (BLS May 2025)
Nurse practitioners in South Carolina earned a median of $123,290 a year ($59.28 an hour) in May 2025, according to the U.S. Bureau of Labor Statistics. That is 7% below the national NP median of $132,300, and it ranks 48th of the 50 states and D.C.
Median salary
$123,290
Median hourly
$59.28
Average (mean)
$124,170
NPs employed
5,670
Source: BLS Occupational Employment and Wage Statistics, May 2025 estimates for Nurse Practitioners (SOC 29-1171), retrieved 2026-10-22. Employed (wage-and-salary) NPs in all settings; excludes self-employed NPs.
NP pay range in South Carolina
Half of South Carolina's nurse practitioners earned between $107,930 and $132,220. The spread from the 10th to the 90th percentile is $63,090, which reflects specialty (family, psychiatric, acute care), setting and region within the state.
| Percentile | South Carolina annual | Hourly equivalent | U.S. annual |
|---|---|---|---|
| 10th percentile | $97,080 | $46.67 | $101,340 |
| 25th percentile | $107,930 | $51.89 | $117,990 |
| Median (50th) | $123,290 | $59.27 | $132,300 |
| 75th percentile | $132,220 | $63.57 | $156,700 |
| 90th percentile | $160,170 | $77.00 | $174,420 |
Hourly equivalent = annual ÷ 2,080 hours, the convention BLS uses to annualize hourly wages. BLS publishes the median hourly wage directly ($59.28); small differences are rounding.
Nurse practitioner vs registered nurse pay in South Carolina
Nurse practitioner, median
$123,290
$59.28/hr · 5,670 employed
Registered nurse, median
$82,360
$39.60/hr · 49,750 employed
In South Carolina the NP median is $40,930 (50%) higher than the RN median. Both figures are BLS estimates for May 2025. The step up requires a graduate degree (MSN or DNP), national board certification in a population focus and state APRN licensure, so the gap is the return on two to four more years of education.
What a median NP paycheck looks like in South Carolina
Gross pay at the South Carolina median, and the federal taxes on it for a single filer taking the 2026 standard deduction. Retirement, insurance and other payroll deductions vary by employer and are not included.
| Yearly | Monthly | Every 2 weeks | |
|---|---|---|---|
| Gross pay (median) | $123,290 | $10,274 | $4,742 |
| Federal income tax | $18,324 | $1,527 | $705 |
| Social Security + Medicare | $9,432 | $786 | $363 |
| South Carolina income tax | Not included (we only publish sourced state tax figures) | ||
Taxes: IRS Rev. Proc. 2025-32 brackets and standard deduction, SSA 2026 wage base. See methodology.
South Carolina vs neighboring states
Median nurse practitioner pay in the states that border South Carolina:
| State | Median salary | Median hourly | vs South Carolina |
|---|---|---|---|
| South Carolina | $123,290 | $59.28 | — |
| Georgia | $129,430 | $62.22 | +$6,140 |
| North Carolina | $128,990 | $62.01 | +$5,700 |
The Nurse Licensure Compact covers RN and LPN licenses only. A nurse practitioner needs an APRN license in each state where they practice.
Frequently Asked Questions
How much do nurse practitioners make in South Carolina?
Nurse practitioners in South Carolina earned a median of $123,290 a year ($59.28 an hour) in May 2025, according to the Bureau of Labor Statistics. The average (mean) was $124,170. That median is 7% below the national NP median of $132,300 and ranks 48th of the 50 states and D.C.
What do the highest-paid nurse practitioners in South Carolina make?
The top 10% of nurse practitioners in South Carolina earned at least $160,170 a year, and the top quarter at least $132,220. The bottom 10% earned less than $97,080. These are BLS percentile estimates for employed NPs across all settings, not offers for a specific job.
How much more do nurse practitioners make than RNs in South Carolina?
The NP median in South Carolina ($123,290) is $40,930 a year, or 50%, above the registered nurse median of $82,360, both from BLS for May 2025. Becoming an NP requires a graduate degree (MSN or DNP), national board certification and state APRN licensure.
What is a nurse practitioner's paycheck in South Carolina?
At the South Carolina median of $123,290, gross pay is about $10,274 a month or $4,742 every two weeks. For a single filer with the standard deduction, 2026 federal income tax plus Social Security and Medicare come to about $27,755 a year. South Carolina state income tax is not included in that figure, so actual take-home is lower.
How many nurse practitioners work in South Carolina?
BLS estimated 5,670 nurse practitioners employed in South Carolina in May 2025, the 21st largest NP workforce of the 50 states and D.C.
About this data
These figures are the Bureau of Labor Statistics' Occupational Employment and Wage Statistics (OEWS) estimates for May 2025, the latest published. OEWS surveys employers, so it measures employed nurse practitioners in all settings and excludes self-employed NPs and locum or travel contract pay. Means are pulled up by high earners, which is why we lead with the median.
See nurse practitioner salary in every state for the full ranking.